Ledezma, the 62-year-old former mayor of metropolitan Caracas, was charged in February 2015 with plotting to overthrow Maduro's government, which he denied.
About 70 percent of Venezuelans say they're boycotting the vote because they think the election's rigged. The opposition disputes the voting figures. Worse, the government stacked the election to its advantage, arranging it so that the constituyente would draw one delegate from each municipality, which disproportionately favored the thinly populated rural areas where Maduro is most popular. The United States, Spain, Mexico, Argentina, Brazil, Peru, Colombia, Canada, Costa Rica and Panama condemned it. Nicaragua and Bolivia praised the vote.
"If they ever got sanctions from the US - that would be completely crippling", says Diego Ferro, co-investment officer at Greylock Capital, a USA firm that owns Venezuelan debt. Hundreds of people have been killed in the streets after protesting Maduro's regime.
Mitzy de Ledezma also said Maduro's regime is responsible for ensuring her husband's life and well-being.
Lopez turned himself in, and was sentenced in 2015 to almost 14 years in prison.
Before their arrest, the men had called for mass protests against President Maduro's decision to create a new Constituent Assembly to change the country's Constitution.
Germany: 'Desirable' for USA to talk to Europeans about Russian Federation sanctions
But it is important the European Commission now looks into countermeasures. "Unfortunately, that is exactly what they are doing. As of Monday, Brussels had not commented the US' sanctions bill and its bearing on European energy firms.
Opposition lawmaker Freddy Guevara said the arrests were aimed at "frightening us and demoralizing us".
In a photo taken lasy month, Venezuela's opposition leader Leopoldo Lopez holds a national flag as he greets supporters outside his home in Caracas, Venezuela, following his release from prison and being placed under house arrest after more than three years in military lockup. But the opposition wants to take the risk and to continue on the streets because for them, it's the only way to actually do something about it.
She released home security camera footage in which four uniformed police officers and three others in civilian garb are seen putting her husband into a vehicle and taking off, with other cars escorting them.
The measures were unusual in that they targeted a sitting head of state, but their reach was mostly symbolic, freezing any USA assets Maduro might have and banning people under U.S. jurisdiction from dealing with him.
"12:27 in the morning: the moment when the dictatorship kidnaps Leopoldo at my house", she said in another tweet.
They are also meant to send a message to the people of Venezuela, she said.
It comes a day after the government held an election for a controversial Constituent Assembly that will supersede the opposition-controlled legislature and rewrite the constitution.
When President Chavez wanted a new constitution, he put it to a referendum and he got a "Yes" vote, Lane said, but President Maduro just declared by edict that he was going to write a new constitution and have all his cronies elected to the Constituent Assembly. On Wednesday, July 26, 13 people were punished for their role in calling the election and violently suppress protests countrywide.