Conflict monitor Syrian Observatory for Human Rights reported on Wednesday the SDF backed by US Special Forces were flushing ISIS militants out of al-Thankanah neighborhood.
The latest air raids hit the IS-held village of Al-Khrayta, 14 kilometres (nine miles) outside Deir Ezzor city.
The Syrian army has lifted the siege to the capital city of Deir al-Zour by breaking into the terror group's defense line around the Brigade 137 base of the Syrian army.
The strikes follow three days of deadly suspected Russian raids in Deir Ezzor province that have killed dozens of civilians, according to the Observatory.
The operation seeks to "oust Daesh from the city and the province completely", the military source said.
"Russian and Syrian regime warplanes are striking IS positions in the city and its outskirts", he added.
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Last week Syrian troops, backed by Russian air attack, broke the siege of two enclaves in and around Deir Az Zor, which had been encircled by ISIL fighters for almost three years.
Much of Deir Az Zor City has been under ISIL control since 2014 with only 40% under government control with about 100,000 civilians.
Moscow intervened in Syria in September 2015 in support of its ally President Bashar al-Assad.
Separately, the Syrian Democratic Forces, a Kurdish-Arab alliance backed by the US-led coalition, is battling IS east of the river.
The US-led Coalition told Rudaw English that as of Tuesday, SDF partner forces "have liberated approximately 42,000 square-kilometers in Syria" which is estimated to be "77 percent of the territory previously held by ISIS".
Although the SDF has yet to reach Deir Ezzor city itself, tribal figures affiliated with the alliance said they were laying the groundwork for governing the city after IS's defeat.