With this result, City has now scored 17 goals unanswered across all competitions, as part of four consecutive victories.
Guardiola, however, admits that it would not be an easy task because fatigue will play a part following their midweek trip to Rotterdam, where they defeated Feyenoord 4-0 in the Champions League.
Liverpool welcome Burnley to Anfield but will be without the suspended Sadio Mane, while free-scoring Manchester City will be eyeing up another victory away at Watford. They were shock 2-0 victors at Southampton in their last outing.
Attacking wise the Blues have started to show signs that they are able to play together, and attack as a unit.
Manchester City will take a lot of stopping on all fronts this season judging by these statistics in the wake of their six-nil win over Watford.
Man City have scored more goals in their last two PL games at Vicarage Road (8) than Watford (7) have in their last 8 at the ground.
Prediction: Manchester United vs Everton
Everton have been a bit inconsistent this season, as they have mixed some impressive displays with some really poor ones. Similar things were said about the returning Wayne Rooney: "I think that he will get the welcome he deserves".
Craig Cathcart (knee), Sebastian Prodl, Younes Kaboul (both hamstring) and Tommy Hoban (cruciate ligament) are all nursing short-to-long-term injury. Miguel Britos serves the second of his three-match ban after being sent off against Brighton.
For City, Raheem Sterling will make his return from the suspension he picked up against Bournemouth, while captain Vincent Kompany will face a late fitness test to see whether the Belgian can battle against his minor calf strain, having missed out on the thumping of Liverpool.
The visitors are huge favourites to claim a win at 4/11 odds.
"We have got to continue like this and on Saturday we have Manchester City at home and a great opportunity to try to stay up with them".
"The way we played as a team, we are so happy", the Spaniard added.
Everton have struggled without him so far but Lukaku said he would be focused only on getting another win. You can get the best odds of 10/1 for our betting tip at Bet365.
Aguero's hat-trick - his sixth in the Premier League and 10th for City - has moved the Argentine only two away from Manchester City's all-time scoring record of 177, set by Eric Brook between 1928 and 1940. For the hosts, Andre Gray and Troy Deeney are available at 15/4 odds. "It is a pleasure to have him with us".