With awards juggernaut Downton Abbey" finished and "Game of Thrones ineligible, this year's Emmys are seen as the first in years in which any show could take home the most prestigious statuettes.
Reed Morano became just the second woman to win the drama series directing Emmy.
"Veep" also won Outstanding Comedy Series in a night dominated by shows with certain political relevance. The former White House press secretary made a surprise Emmys appearance, wheeling in his own podium.
With previous two-time victor "Game of Thrones" absent because it fell outside the eligibility window, "This Is Us" and "The Handmaid's Tale" are among an unprecedented number of newcomers that include "The Crown", "Stranger Things" and "Westworld". "The writing was great and the exploration of that particular period was beautifully done". "You are fearless and strong and smart", she said.
"I had survived that thing that I was so afraid of", Waithe told The Times of her coming-out experience. She now holds the record for most awards won by an actress for the same role!
Fiona Dourif, star of BBC America's Dirk Gently's Holistic Detective Agency, told AFP she was now watching The Handmaid's Tale and hoped to see Moss rewarded, as well as Stranger Things. "The story has a finality to it that feels end-of-series".
Mexico: More than 200 killed in powerful earthquake
Hollywood actress Eva Longaria also posted a message on social media explaining that her family and husband are safe in Mexico . The frightening tragedy came on the anniversary of a devastating 1985 quake that killed thousands in and around the city.
Donald Glover won best comedy actor for his hip-hop themed show "Atlanta". "There are so many avenues for storytelling and there are so many more storytellers than there used to be because of it", she said.
Alexander Skarsgard and Laura Dern were named best supporting actors in a limited series or movie for "Big Little Lies". It was the first statue for the eight-time nominee.
The series is based on Margaret Atwood's 1985 novel, and the celebrated Canadian author received a standing ovation when she joined the cast and producers onstage as they accepted the Emmy. Her first Emmy win was when she was 35.
"Well, I think this is a dream, you know". I adore Cloris Leachman.
The actress beat out Pamela Adlon, Jane Fonda, Allison Janney, Ellie Kemper, Tracee Ellis Ross and Lily Tomlin for this year's outstanding lead actress in a comedy series award.
The actress on September 17 took home her sixth consecutive win for best actress in a comedy category for her role on "Veep", placing her in the history books for most Emmys won by a single performer for one role.
Louis-Dreyfus has won every year she's played mercurial president Meyer, and this was her 24th overall Emmy nomination.