Trump is due on Wednesday to recognise Jerusalem as Israel's capital and set in motion the relocation of the U.S. Embassy to the ancient city, senior U.S. officials said, a decision that upends decades of U.S. policy and risks fuelling further violence in the Middle East.
Debate on the issue is in many ways the crux of the conflict between Israel and Palestine, which is backed by Arab leaders, including Saudi Arabia, and the wider Islamic world.
Trump is also expected to approve moving the U.S. embassy from Tel Aviv to Jerusalem, although not immediately.
"At the same time, I would like to make a heartfelt appeal for everyone's commitment to respect the city's status quo, in conformity with the pertinent United Nations Resolutions", he said.
Pope Francis made foreign politics the focus of his weekly general audience, pinpointing the highlights of his recent trip to Myanmar and Bangladesh and calling on the global community not to destabilize the current situation in Jerusalem.
The pope said he was "profoundly concerned" about recent developments regarding Jerusalem, which he called a "special vocation for peace" and a sacred place for Christians, Jews and Muslims.
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In his remarks, Pope Francis said the Holy Land was the "land par excellence of dialogue between God and mankind".
Pope Francis also spoke about the necessary conditions for true dialogue.
Prior to his General Audience, the Pope met with a Palestinian delegation of religious and intellectual leaders in the Vatican, in which he called for a dialogue marked by "reciprocal respect" for the rights of everyone in the Holy Land while expressing his hope for "peace and prosperity" for the Palestinian people.
Francis, former Pope Benedict and Pope John Paul II all visited Israel and Palestinian territories. Moreover - similar steps could be interpreted as a clear signal for the rejection of Washington's two-state solution to the conflict in the region.
"They came to the Vatican with the intention of establishing a joint working group".
The Vatican signed its first treaty with the "State of Palestine" the following year.