Some of Winfrey's close friends have reportedly been urging her to run, CNN reported.
In the months after the congressional elections, halfway through Trump's four-year term, Democratic presidential challengers are likely to begin announcing their candidacies to run against him. "She would absolutely do it". The boost comes amid rising speculation that Winfrey could have aspirations for a United States presidential run, despite her denial during a backstage interview.
The touchstone of Winfrey's speech was the #MeToo movement.
Winfrey told the audience: "For too long, women have not been heard or believed if they dared to speak their truth to the power of those men, but their time is up".
"She had that room in her hands".
With nearly three years to run, there is still all to play for in the 2020 presidential election.
Oprah also branched out into acting.
The president added that he liked her, "but I don't think she's going to run".
Winfrey, when asked backstage if she planned to run for president, replied, "I don't. But now she doesn't have a choice".
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"I slept on it and came to the conclusion that the Oprah thing isn't that insane", tweeted Dan Pfeiffer, a former senior advisor to Barack Obama, the president Winfrey was credited with helping to elect in 2008. Singer and actor Leslie Odom Jr commented: "She's running".
Wow, it looks like "a new day is on the horizon!"
Even she is facing criticism, however, from those who haven't paid any attention to her history of speaking out about abuse or who have failed to learn the lesson we've all been hearing. She is credited with roles in almost 30 movie and TV productions, including a role in director Steven Spielberg's The Colour Purple that earned her an Oscar nomination for best supporting actress.
Jones tweeted: "It's been an absolute honour to support and stand by you since the beginning my dear @Oprah".
When the industry you work in is toxic, you sometimes have to hold your nose and get through before you can change it, or you leave, and never get the chance.
Apollo 13 director Ron Howard described Winfrey's speech as "the most extraordinary and inspiring moment".
And I have tried many, many, many times to explain what a moment like that means to a little girl, a kid watching from the cheap seats as my mom came through the door, bone exhausted from cleaning other people's houses.
"I have no problem with Oprah Winfrey. I also know that after years of watching the Oprah show, you also always have the right to change your mind". Many seemed to be stunned that Ivanka tweeted such a response. Yes it is. May we all greet it with hope, resolve and faith. I'm assuming she'd run as a Democrat, since that's where her worldview and sensibilities best fit.
Singer and producer Brad Walsh wrote: "She is quite literally the Antitrump".
But given her connections, Winfrey might have a fund-raising advantage over her rivals in liberal Hollywood, which is often called an automatic teller machine for Democratic candidates.