And there's a huge game between West Brom and Southampton, who sit two places and three points above them in the segment of the table that no grown adult should ever refer to as "the drop zone". Stones is the most likely of the missing players to return for the next game. The burden has fallen on first-team regulars to pick up the slack and there is a danger that fatigue could have a serious effect going into the final months of the season.
The England worldwide has made 15 league appearances this season apart from featuring nine times in domestic cup competitions and the Champions League.
De Bruyne, on the other hand, played both legs of the Carabao Cup semifinal victory over Bristol City as well as the fourth round FA Cup win over Cardiff City, meaning he has played a total of 2,975 minutes in all competitions - 174 minutes more than Matic.
The rate of games has been relentless. In contrast to Matic, the United midfielder has made just eight appearances over the same period.
"We played two-and-a-half days ago". Guardiola is now giving his whole squad time off until Wednesday with their next match against Leicester not until Saturday.
José Mourinho concedes the Premier League title to Manchester City
However, the Gunners have been handed a lifeline in the race for the top four as rivals Liverpool and Spurs played out a 2-2 draw on Sunday while Chelsea are in crisis having suffered a second consecutive heavy defeat - this time a 4-1 loss at Watford last night.
City took the lead via a thumping strike from Danilo, however they failed to make good of subsequent chances.
Take a look through the gallery above to see the latest Premier League Team of the Week based on stats.
Of the forthcoming rest, Guardiola said it wouldn't be limited to the players.
Barcelona set new record after Pique's late equaliser
But he chose to bounce back and silence the crowd with a goal that would eventually decide the course of the game. On our part, we will not get into this game or provocations, we respect everyone.