There were hopes that he would return in time for Tuesday night's second leg match against Sevilla but the Frenchman was absent at United's Carrington training base on Monday morning.
Mourinho went with a 4-2-3-1 formation, which shifted to a 4-4-2 when United did not have possession.
Carrick has won 18 trophies in 12 years at United, including five Premier League titles and the Champions League in 2008.
That was the first official meeting between both clubs, and it will also be the first official match for the Andalucia side at Old Trafford.
Here's something no one saw coming - an honest to goodness compelling Manchester United-Liverpool game.
With Pogba and Herrera doubtful, Mourinho has little options in the midfield.
Tom Crean would have 'keen interest' in Georgia job
Georgia lost Friday to Kentucky in the SEC tournament quarterfinals and finished 18-15 overall, 7-11 in the sec this season. Fox now ranks third in school history in total wins behind Hugh Durham and Herman Stegeman.
At times, it seemed like he was the only one who noticed UEFA now puts the Europa League victor into next season's Champions League.
Find out what time Manchester United vs Sevilla gets underway where you are in the world. In a hectic season of all-round football, it would be essential to rest the big names in the first team.
Anthony Martial is fit and available for Manchester United's Champions League round of 16, second-leg game at home to Sevilla, manager Jose Mourinho said yesterday.
Chris Smalling grabbed one back before a composed Romelu Lukaku finish drew United level. Alexis Sanchez had been underwhelming on the left anyway so Mourinho may consider utilising the Chilean more centrally again and allowing Rashford, a player surely imbued with confidence, to slot in on the left once more.
"I think with all the minutes around the two goals we conceded then a draw would have been deserved for us, but because we made these two mistakes we have to take the result like it is".
United are in a good run of form this season, and they seem to be getting hotter at the ideal time. "Yes I will, of course I will, because it's getting hard", said Pardew.
"You have to give the guy some credit for getting footballers to sing from his hymn sheet, with the structure he puts into a team making it tough to break them down and he tends to have a couple of creative players who can make the most of a chance when it comes their way".
This season, there is no Europa League safety net, but Manchester United doesn't have the same worries about Champions League qualification.
"Liverpool is Liverpool, it is a big match, it is a match against a direct competition for the top four, but nothing is decided yet".