Jose Mourinho's side were stunned by the two late strikes from Frenchman Ben Yedder and, although Romelu Lukaku pulled a goal back, United's once promising European campaign came to a sorry end.
Jose Mourinho turned to Pogba to influence the game at a crucial stage but the France worldwide was arguably United's worst performer and he gave the ball away a number of times in good areas.
"We had good periods, we didn't have great control over the game, but I can't say there was anything wrong with my players and their intention to play", he said.
United fans will probably all have different opinions but the question was put to Rio Ferdinand ahead of United's Champions League second-leg vs Sevilla. "I don't want to make a drama out of this defeat".
Mourinho was on the winning side that night as Real Madrid manager and also sent United out of the last 16 when Porto boss in 2004.
"That's football, we lost, but tomorrow is another day and Saturday is another match".
Hesson confident Taylor will be fit for day-night Test against England
But at the end, before the last match, New Zealand and England won two matches each and so, last match was nearly final no doubt. For now, the focus will switch to red-ball cricket as New Zealand prepare to face England in a two-match Test series at home .
United went behind deep into the second half when substitute Wissam Ben Yedder came in to break the deadlock with a precise finish. It would be naïve to think that they will not fight in this game.
"It's a big comp, it would be the first time in 60 years for us to get through to this stage".
Jesse Lingard forced a fine one-handed save from Sergio Rico and Rashford fizzed across the face of goal when United unleashed their first threats, but Correa got away an attempt that bobbled wide as tension began to rise.
Yet, the Belgian almost made the breakthrough with United's best move of the opening period when he latched onto Alexis Sanchez's layoff and his powerful effort was turned behind by Sergio Rico.
Man United should not have been caught cold by Sevilla substitute Ben Yedder, considering his Champions League exploits against Liverpool this season.
Mourinho's gamble on Fellaini appeared to have largely backfired as he failed to impose his physical presence on Sevilla's ball players in midfield.