Putin-backed Syrian President Bashar al-Assad is suspected of being behind the attack - and Russian Federation earlier warned to shoot down any United States missiles fired in the country.
Victims of Sunday's chemical weapons attack in Douma, Syria.
Moscow and Damascus have called on the Organization for the Prohibition of Chemical Weapons (OPCW) to investigate the attack and find the real perpetrators.
Ms Zakharova said that a possible USA missile strike could be an attempt to destroy evidence of an alleged chemical weapon attack in the Syrian town of Douma.
Earlier on Wednesday it warned Russian Federation about the intention to strike at Syria "smart" missiles and suggested Moscow to prepare for this.
"Bolton just last month had an op-ed in the Wall Street Journal advising preemptive strikes on North Korea, justified in his words by saying that 'given gaps in intelligence about North Korea, we should not wait until the very last minute, '" she said.
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U.S. President Donald Trump on Wednesday tweeted that he would strike Syria with missiles warning Moscow not to shoot them down, amid tensions with Russian Federation.
Earlier today Mr Trump said: "Russia vows to shoot down any and all missiles fired at Syria".
Dan Mahaffee, senior vice president and director of policy at the Center for the Study of the Presidency and Congress, told Xinhua that Trump's Twitter account has become a direct pipeline to the thinking of the president and, in this instance, the thinking of the commander-in-chief of the US military at a time of global tension. But he has threatened military action in response to Syria's suspected chemical attack, which activists and rescuers say killed at least 40 people.
He said: "We hope that there will be no point of no return - that the USA and their allies will refrain from military action against a sovereign state".
If Trump fulfills his threat, the most likely targets for attack will be Syrian military or government facilities, Kwiatkowski predicted. Or perhaps even worse given that Trump isn't publicly laying out a broad strategy of how to solve the problems surrounding Syrian President Bashar al-Assad but rather previewing actual missile launches? "Stop the arms race?" - asks the American President.
"Much of the bad blood with Russia is caused by the Fake & Corrupt Russia Investigation, headed up by the all Democrat loyalists, or people that worked for Obama", Trump claimed.
The Syrian Foreign Ministry has denied the accusation, calling rebels' claims "premeditated pretexts".