Boston will play as the home team in the first Major League Baseball games to be held in Europe, on June 29 and June 30, 2019.
As part of the two-year deal another series will be played in London in 2020.
Mr Manfred said: "The stadium infrastructure in this city gives Major League Baseball every opportunity to put on a first-class event. In future years there may be many more games in London and maybe a baseball team permanently".
"With the success of National Football League and NBA here, London is now the major hub for American sport outside the United States". "All the hard work has paid off".
The 2019 matches are set for June 29-30, with the Red Sox designated as the home team, in what will be the first regular-season Major League Baseball fixtures staged in Europe.
Qantas pressured to adopt one-China policy over Taiwan
As of Monday afternoon, the post had attracted more than 23,000 comments , a lot of them critical of the US. Hong Kong and Macau are former European colonies that are now part of China but run largely autonomously.
Khan said: "London is the sporting capital of the world".
Boston Red Sox joint owner John W Henry. There were significant challenges that had to be overcome. This series will surely be the most significant global event to date for Major League ball.
Yankeees managing general partner Hal Steinbrenner was on hand at Tuesday's news conference along with Major League Baseball commissioner Rob Manfred, Red Sox principal owner John Henry and London mayor Sadiq Khan. "I can't wait to hear someone shout "play ball" at London Stadium". Two of the most recognizable teams are once again two of the best. "Bringing these storied teams together for British fans - who have such a profound appreciation for sports at the highest level - only adds to the unique allure of one of the world's greatest sporting rivalries".
The stadium, which hosted the 2012 Olympics and is now home to West Ham, will be reconfigured for baseball, with 55,000 seats in place for the series. Three more are scheduled for this year.