On Monday, high-profile Brexiteer and Conservative MP Johnson announced he was resigning from the Cabinet, following the agreement of a Brexit proposal that would see the United Kingdom retain close links to the European Union after exiting the organisation.
Some Brexiteers think the most crucial issue is to ensure that Britain actually leaves the European Union in March next year, and feel that whatever arrangements Mrs May has secured can always be renegotiated once that point has been reached.
"I think what Boris said was, in a way, what a lot of people feel out there that somehow we should have been being much more up front and optimistic about our country".
The three resignations provided the backdrop to May giving a statement to MPs about her Brexit plan - agreed by her Cabinet at a crunch summit in the country retreat of Chequers on Friday.
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Trade Representative Lighthizer "to identify $200 billion worth of Chinese goods for additional tariffs at a rate of ten percent". Trump needs to be careful that he doesn't go too far and cross a red line and he's very close to doing that right now.
Brexit-supporting lawmakers were angered by the proposals, saying they would keep Britain tethered to the bloc and unable to change its rules to strike new trade deals around the world.
Brexit minister Steve Baker and unpaid parliamentary aides Conor Burns and Chris Green also resigned.
But it soon began to unravel, when Davis resigned late on Sunday and launched a no-holds-barred attack on her plan, calling it "dangerous" and one which would give "too much away, too easily" to European Union negotiators, who would simply ask for more.
If she chose to fight, she would need the support of more than 50% of Conservative MPs - now 159 - in the confidence vote to stay in office. "Mr Speaker, this is the right Brexit", she said to jeers from the opposition Labour Party.
Responding to the news, Royal Pharmaceutical Society English board chair Sandra Gidley told C+D she "wishes Matthew Hancock the best of luck in his new and challenging role". "It is the Brexit that will deliver on the democratic decision of the British people", May told parliament.
Long before the Brexit referendum and its aftermath, the Conservative Party was split on Europe, and May has struggled to unite the warring wings under her leadership.